Early and late CNS-effects of corona virus infection in rats.
Identifieur interne : 001E99 ( Main/Exploration ); précédent : 001E98; suivant : 001F00Early and late CNS-effects of corona virus infection in rats.
Auteurs : K. Nagashima ; H. Wege ; V. Ter MeulenSource :
- Advances in experimental medicine and biology [ 0065-2598 ] ; 1978.
Descripteurs français
- KwdFr :
- Animaux, Antigènes viraux (analyse), Encéphalite (anatomopathologie), Encéphalite (immunologie), Encéphalite (microbiologie), Encéphalomyélite (microbiologie), Infections à Coronaviridae (anatomopathologie), Infections à Coronaviridae (physiopathologie), Maladies démyélinisantes (anatomopathologie), Maladies démyélinisantes (microbiologie), Paralysie (anatomopathologie), Paralysie (microbiologie), Rats, Virus de l'hépatite murine (immunologie).
- MESH :
- analyse : Antigènes viraux.
- anatomopathologie : Encéphalite, Infections à Coronaviridae, Maladies démyélinisantes, Paralysie.
- immunologie : Encéphalite, Virus de l'hépatite murine.
- microbiologie : Encéphalite, Encéphalomyélite, Maladies démyélinisantes, Paralysie.
- physiopathologie : Infections à Coronaviridae.
- Animaux, Rats.
English descriptors
- KwdEn :
- Animals, Antigens, Viral (analysis), Coronaviridae Infections (pathology), Coronaviridae Infections (physiopathology), Demyelinating Diseases (microbiology), Demyelinating Diseases (pathology), Encephalitis (immunology), Encephalitis (microbiology), Encephalitis (pathology), Encephalomyelitis (microbiology), Murine hepatitis virus (immunology), Paralysis (microbiology), Paralysis (pathology), Rats.
- MESH :
- chemical , analysis : Antigens, Viral.
- immunology : Encephalitis, Murine hepatitis virus.
- microbiology : Demyelinating Diseases, Encephalitis, Encephalomyelitis, Paralysis.
- pathology : Coronaviridae Infections, Demyelinating Diseases, Encephalitis, Paralysis.
- physiopathology : Coronaviridae Infections.
- Animals, Rats.
Abstract
The mouse hepatitis virus strain JHM was injected intracerebrally into newborn and weanling rats. Three types of diseases were observed: 1. Acute panencephalitis: Almost all suckling rats became moribund within 6 days. Histologically severe panencephalitis with demyelinating foci was noticed; the foci were similar to those found in mice. Virus was easily detectable in the oligodendroglial cells and neurons both by immunofluorescence and electron microscopy. Infectious virus could be isolated. 2. Subacute demyelinating encephalomyelitis (SDE): Three weeks after infection of weanling rats, about 35% of the animals developed paralysis. Neuropathologically, demyelination with a striking predilection for white matter was observed in the brain stem, optic nerve and spinal cord. Virus was detectable by electron microscopy in degenerating oligodendroglial cells only, which corresponded to the results obtained by the immunofluorescent techniques. Infectious virus could be recovered. 3. Chronic progressive paralysis: Inoculated weanling rats without SDE developed 6 to 8 months later a slowly progressing paralysis of the legs. Hydrocephalus and myelomalacia were present. Viral "footprints" could not be detected.
DOI: 10.1007/978-1-4684-2514-7_28
PubMed: 211826
Affiliations:
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Le document en format XML
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Nagashima</name></author><author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H" last="Wege">H. Wege</name></author><author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V" last="Ter Meulen">V. Ter Meulen</name></author></analytic><series><title level="j">Advances in experimental medicine and biology</title><idno type="ISSN">0065-2598</idno><imprint><date when="1978" type="published">1978</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Viral (analysis)</term><term>Coronaviridae Infections (pathology)</term><term>Coronaviridae Infections (physiopathology)</term><term>Demyelinating Diseases (microbiology)</term><term>Demyelinating Diseases (pathology)</term><term>Encephalitis (immunology)</term><term>Encephalitis (microbiology)</term><term>Encephalitis (pathology)</term><term>Encephalomyelitis (microbiology)</term><term>Murine hepatitis virus (immunology)</term><term>Paralysis (microbiology)</term><term>Paralysis (pathology)</term><term>Rats</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes viraux (analyse)</term><term>Encéphalite (anatomopathologie)</term><term>Encéphalite (immunologie)</term><term>Encéphalite (microbiologie)</term><term>Encéphalomyélite (microbiologie)</term><term>Infections à Coronaviridae (anatomopathologie)</term><term>Infections à Coronaviridae (physiopathologie)</term><term>Maladies démyélinisantes (anatomopathologie)</term><term>Maladies démyélinisantes (microbiologie)</term><term>Paralysie (anatomopathologie)</term><term>Paralysie (microbiologie)</term><term>Rats</term><term>Virus de l'hépatite murine (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes viraux</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphalite</term><term>Infections à Coronaviridae</term><term>Maladies démyélinisantes</term><term>Paralysie</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Encéphalite</term><term>Virus de l'hépatite murine</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Encephalitis</term><term>Murine hepatitis virus</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Encéphalite</term><term>Encéphalomyélite</term><term>Maladies démyélinisantes</term><term>Paralysie</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Demyelinating Diseases</term><term>Encephalitis</term><term>Encephalomyelitis</term><term>Paralysis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronaviridae Infections</term><term>Demyelinating Diseases</term><term>Encephalitis</term><term>Paralysis</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections à Coronaviridae</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronaviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The mouse hepatitis virus strain JHM was injected intracerebrally into newborn and weanling rats. Three types of diseases were observed: 1. Acute panencephalitis: Almost all suckling rats became moribund within 6 days. Histologically severe panencephalitis with demyelinating foci was noticed; the foci were similar to those found in mice. Virus was easily detectable in the oligodendroglial cells and neurons both by immunofluorescence and electron microscopy. Infectious virus could be isolated. 2. Subacute demyelinating encephalomyelitis (SDE): Three weeks after infection of weanling rats, about 35% of the animals developed paralysis. Neuropathologically, demyelination with a striking predilection for white matter was observed in the brain stem, optic nerve and spinal cord. Virus was detectable by electron microscopy in degenerating oligodendroglial cells only, which corresponded to the results obtained by the immunofluorescent techniques. Infectious virus could be recovered. 3. Chronic progressive paralysis: Inoculated weanling rats without SDE developed 6 to 8 months later a slowly progressing paralysis of the legs. Hydrocephalus and myelomalacia were present. Viral "footprints" could not be detected.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Nagashima, K" sort="Nagashima, K" uniqKey="Nagashima K" first="K" last="Nagashima">K. Nagashima</name><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V" last="Ter Meulen">V. Ter Meulen</name><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H" last="Wege">H. Wege</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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